Our goal is to understand structural changes and elucidate their molecular mechanisms and roles in biological phenomena of organs, such as the nervous system. In particular, we are focusing on intercellular communications and organelle dynamics. Toward this goal, we uses multidisciplinary light and electron microscopic approaches including immunohistochemistry, in situ hybridization, live imaging of cells and organs with transgenic animals and viral vectors, and 3 dimensional ultrastructural analyses with scanning electron microscopy, which are combined with physiological analyses.

(1) Structuralization and regulation in formation, functions and diseases of myelin

Cellular interactions play essential roles in the nervous system. Myelin formation around neuronal axons increases the velocity of nerve conduction and is critical for survival of the axons. Pathological loss of myelin and dysmyelination are associated with various diseases, and recent studies revealed that myelin plasticity under exercise and developmental circumstances affects learning and social behavior. We would like to understand structural and functional changes and develop methods for their regulation in myelin formation and diseases.

Review Ohno and Ikenaka, Neurosci Res. 2019 Feb;139:48-57. doi: 10.1016/j.neures.2018.08.013.

(2) Revealing dynamics and functions of mitochondria

Abnormal dynamics of mitochondria, which has multiple roles in the cells, are involved in pathophysiology of various diseases. In addition, mitochondria interact with the other organelles, and such interactions are deeply associated with their functional regulation. We are would like to understand the mechanisms and roles of their dynamics and interactions and trying to develop technologies for their regulation.

Review Sui et al., Adv Exp Med Biol. 2019;1190:145-163. doi: 10.1007/978-981-32-9636-7_10.