黒岩憲二

【職名】講師

【出身大学】東京理科大学　理工学部　応用生物科学科

【学位】博士（理学）2000年3月

【職歴】

2000年4月　科学技術振興機構（JST）・戦略的創造研究推進事業さきがけ（PRESTO）「タイムシグナルと制御」領域、「免疫の調節機構、その制御と新しい治療コンセプト」ポスドク
2000年4月−2002年7月　筑波大学臨床医学系消化器外科清野研一郎グループ
2002年8月−2003年10月 千葉大学 理化学研究所免疫アレルギー科学総合研究所
2004年4月　東京理科大学　理工学部　応用生物科学科　助手
2007年3月　自治医科大学　生化学講座　機能生化学研究室　助教

【着任年月日】2007年3月1日　助教（生化学講座）
2013年4月1日　学内講師（生化学講座）

【専門分野】細胞生物学、生化学

【研究活動】

学生時代から今日まで細胞増殖、免疫、神経細胞の分化など幅広く。１９年度からはミトコンドリアの機能について。

Researchmap Link

以下のリンクをクリックしてください: researchmap

【教育活動】

  • 「生化学」「学生実習」「生命科学1、2」(分担)

【ひとこと】研究、好きです。大好きです。

【原著論文】

  • Tominaga K, Sakashita E, Kasashima K, Kuroiwa K, Nagao Y, Iwamori N, Endo H. "Tip60/KAT5 Histone Acetyltransferase Is Required for Maintenance and Neurogenesis of Embryonic Neural Stem Cells." International Journal of Molecular Sciences 24(3) 2113-2113 2023.
  • Kuroda R, Tominaga K, Kasashima K, Kuroiwa K, Sakashita E, Hayakawa H, Kouki T, Ohno N, Kawai K, Endo H. "Loss of mitochondrial transcription factor A in neural stem cells leads to immature brain development and triggers the activation of the integral stress response in vivo. PLos One; 16 : e0255355, 2021.
  • Mashiko T, Sakashita E, Kasashima K, Tominaga K, Kuroiwa K, Nozaki Y, Matsuura T, Hamamoto T, Endo H. "Developmentally-regulated RNA-binding Protein 1 (Drb1)/RNA-binding Motif Protein 45 (RBM45), a Nuclear-cytoplasmic Trafficking Protein, Forms TAR DNA-binding Protein 43 (TDP-43)-mediated Cytoplasmic Aggregates." J. Biol. Chem. 2016;291:14996-15007.
  • Yamamoto, S., Nagao, Y., Kuroiwa K, Hakamata, Y., Ichida, M., Saito-Ohara, F., Tominaga, K., and Endo, H. : Rapid selection of XO embryonic stem cells using Y chromosome-linked GFP transgenic mice. Transgenic Res.; 23 : 757-765, 2014.
  • Tetsuka, S., Tominaga, K., Ohta, E., Kuroiwa K, Sakashita, E., Kasashima, K., Hamamoto, T., Namekawa, M., Morita, M., Natsui, S., Morita, T., Tanaka, K., Takiyama, Y., Nakano, I., Endo, H. "Paraneoplastic cerebellar degeneration associated with an onconeural antibody against creatine kinase, brain-type." J. Neurol. Sci. 2013;335:48-57.
  • Akimoto, C., Sakashita, E., Kasashima, K, Kuroiwa K, Tominaga, K., Hamamoto, T., and Endo, H. : Translational repression of the McKusick-Kaufman syndrome transcript by unique upstream open reading frames encoding mitochondrial proteins with alternative polyadenylation sites. Biochim. Biophys. Acta; 1830 : 2728-2738, 2013.
  • Kuroiwa K, Torikai, Y., Osawa, M., Nakashima, T., Nakashima, M., Endo, H., and Arai, T. : Epitope determination of anti rat thy-1 monoclonal antibody that regulates neurite outgrowth. Hybridoma (Larchmt); 31(4) : 225-32, 2012.
  • Ohto-Ozaki, H., Kuroiwa K, Mato, N., Matsuyama, Y., Hayakawa, M., Tamemoto, H., and Tominaga, S. : Characterization of ST2 transgenic mice with resistance to IL-33. Eur. J. Immunol.; 40(9) : 2632-42, 2010.
  • Kokubo, J., Nagatani, N., Hiroki, K., Kuroiwa K, Watanabe, N., and Arai, T. : Mechanism of destruction of microtubule structures by 4-hydroxy-2-nonenal. Cell Struct. Funct.; 33(1) : 51-9, 2008.
  • Kimoto, K., Aoki, T., Shibata, Y., Kamisuki, S., Sugawara, F., Kuramochi, K., Nakazaki, A., Kobayashi, S.,Kuroiwa K, Watanabe, N., and Arai, T. : Structure-activity relationships of neoechinulin A analogues with cytoprotection against peroxynitrite-induced PC12 cell death. J. Antibiot. (Tokyo); 60(10) : 614-21, 2007.
  • Aoki, T., Kamisuki, S., MKimoto, M., Ohnishi, K., Takakusagi, Y., Kuramochi, K., Takeda, Y. Nakazaki, A., Kuroiwa K, Ohuchi, T., Sugawara, F., Arai T., and Kobayashi, S. : Total Synthesis of (-)-Neoechinulin A, Synlett ; No.5, 0677-0680, 2006. [Synlett]
  • Kanda, M., Ohto-Ozaki, H., Kuroiwa K, Tominaga, S., Watanabe, E., and Iwahana, H. : Elevation of ST2 protein levels in cerebrospinal fluid following subarachnoid hemorrhage. Acta Neurol. Scand.; 113(5) : 327-33, 2006. [Pubmed]
  • Iwahana, H., Hayakawa, M., Kuroiwa K, Tago, K., Yanagisawa, K., Noji, S. and Tominaga, S. : Molecular cloning of the chicken ST2 gene and a novel variant form of the ST2 gene product, ST2LV.Biochim. Biophys. Acta.; 1681(1):1-14, 2004. [Pubmed]
  • Lecart, S., Lecointe, N., Subramaniam, A., Alkan, S., Ni, D., Chen, R., Boulay, V., Pene, J., Kuroiwa K, Tominaga, S., and Yssel, H. : Activated, but not resting human Th2 cells, in contrast to Th1 and T regulatory cells, produce soluble ST2 and express low levels of ST2L at the cell surface. Eur. J. Biochem.; 32, 2979-2987, 2002. [Pubmed]
  • Tago K., Funakoshi M., Mano H., Yanagisawa K., Hayakawa M., Kuroiwa K, Iwahana H., Kasahara T., Tominaga S.: Presence of a genistein-responsive inhibitory mechanism on interleukin-1alpha-induced NF-kappaB activation. Eur. J. Biochem.; 268, 6526-6533, 2001. [Pubmed]
  • Kuroiwa K, Arai, T., Okazaki, H., Minota, S., and Tominaga, S. : Identification of Human ST2 protein in the sera of patients with autoimmune diseases.Biochem. Biophys. Res. Commun.; 284, 1104-1108, 2001. [Pubmed]
  • Oshikawa, K., Kuroiwa K, Tago, K., Iwahana, H., Yanagisawa, K., Ohno, S., Tominaga, S., and Sugiyama, Y. : Elevated soluble ST2 protein levels in sera of asthma patients with an acute exacerbation. Am. J. Respir. Crit. Care Med.; 164, 277-281, 2001. [Pubmed]
  • Oshikawa K., Kuroiwa K, Tokunaga T., Kato T., Hagihara S., Tominaga S., Sugiyama Y.: Acute eosinophilic pneumonia with increased soluble ST2 in serum and bronchoalveolar lavage fluid. Respir. Med.; 95, 532-533, 2001. [Pubmed]
  • Li, HJ., Tago, K., Io, K., Kuroiwa K, Arai, T., Iwahana, H., Tominaga, S, and Yanagisawa, K. : The Cloning and Nucleotide Sequence of Human ST2L cDNA.Genomics; 67, 284-290, 2000. [Pubmed]
  • Kuroiwa K, Li, HJ., Tago, K., Iwahana, H., Yanagisawa, K., Komatsu, N., Oshikawa, K., Sugiyama, Y., Arai, T., and Tominaga, S : Construction of ELISA System to Quantify Human ST2 Protein in Sera of Patients. Hybridoma; 19, Number 2, 151-159, 2000. [Pubmed]
  • Tominaga, S., Kuroiwa K, Tago, K., Iwahana, H., Yanagisawa, K., and Komatsu, N. : Presence and Expression of a Novel Variant Form of ST2 Gene Product in Human Leukemic Cell Line UT-7/GM. Biochem. Biophys. Res. Commun.; 264, 14-18, 1999. [Pubmed]
  • Iwahana, H., Yanagisawa, K., Ito-Kosaka, A., Kuroiwa K, Tago, K., Komatsu, N., Katashima, R., Itakura M. and Tominaga, S. : Different promoter usage and multiple transcription initiation sites of the interleukin-1 receptor-related human ST2 gene in UT-7 and TM12 cells. Eur. J. Biochem.; 264, 397-406, 1999. [Pubmed]
  • Yanagisawa, K., Naito, Y., Kuroiwa K, Arai, T., Furukawa, Y., Tomizuka, H., Miura, Y., Kasahara, T., Tetsuka, T and Tominaga, S. : The Expression of ST2 Gene in Helper T Cells and the Binding of ST2 Protein to Myeloma-Derived RPMI8226 Cells. J. Biochem.; 121, 95-103, 1997. [Pubmed]