自治医科大学 感染症学部門

研究

臨床研究に関する公開情報

課題名 研究期間 情報公開文書
国民健康保険・後期高齢者医療制度レセプトデータおよび予防接種データを用いた疫学研究 2026.3～2036.3 臨大25-116
大規模民間レセプトデータベースを活用した感染症疫学研究 2025.11～2031.3 臨大25-113
わが国の抗菌薬処方動向 (2016–2025) の解析 2025.9～2030.3 臨大25-071
帯状疱疹と認知症リスクの関連：匿名医療保険等関連情報データベース（NDB）を用いた後ろ向きコホート研究 2025.4～2030.3 臨大25-004
レセプトデータベースを用いた帯状疱疹, ニューモシスチス肺炎, ノカルジア感染症の臨床疫学研究 2024.10～2030.3 臨大24-112
AmpC型β-ラクタマーゼを産生する腸内細菌科細菌の分子疫学と院内での伝播様式に関する研究 2022.6～2027.12 臨大25-123
2剤レジメン(DTG/3TC)への切り替えが体重や代謝に与える影響 -ランダム化オープンラベル試験 2022.7～2027.3 （臨附22-107）
新型コロナウイルス感染症の病態理解と治療法検討のための多施設共同研究 2020.8～2026.7 臨附24-080

研究内容

2026 2025 2024 2023 2022

2026

  1. Matsumura M, Kanda N, Hatakeyama S, Dhaliwal G. Immune Interference. N Engl J Med. 2026 May 7;394(18):1847-1853. doi: 10.1056/NEJMcps2511351..
  2. Adachi-Katayama M, Kanda N, Sasakura S, Hatakeyama S. Epidemiology of herpes zoster and postherpetic neuralgia in Japan: analysis of a large-scale claims database. BMC Infect Dis. 2026 Jan 10;26(1):287. doi: 10.1186/s12879-026-12534-0.
  3. Takeuchi JS, Matsunaga N, Tsukada A, Iwamoto N, Fuwa N, Ichikawa T, Kato Y, Tomita Y, Kitagawa H, Yamato M, Aoyagi T, Hagiya H, Hase R, Hatakeyama S, Inaba T, Izumikawa K, Takesue Y, Kimura M, Ohmagari N. Saliva as a Reliable and Non-invasive Sample for Detecting Influenza A in Severe Acute Respiratory Infection Cases. Cureus. 2026 Jan 5;18(1):e100872. doi: 10.7759/cureus.100872.

2025

  1. Kawaguchi T, Watanabe S, Liu Y, Aiba Y, Tan XE, Veeranarayanan S, Miyanaga K, Sasahara T, Shimamori Y, Alessa O, Hidaka Y, Thu M, Kaewprasert O, Rani V, Hossain MR, Palaninathan V, Esakkiraj P, Hakim TFN, Maruthan K, Fernandes PB, Arbaah M, Batbold A, Maniruzzaman, Hossain S, Sugano T, Uematsu H, Wannigama DL, Kiga K, Cui L. Gene-specific reversal of carbapenem-resistant Pseudomonas aeruginosa via phage-delivered CRISPR-Cas13a. NPJ Antimicrob Resist. 2025;3(1):98. doi: 10.1038/s44259-025-00167-3.
  2. Yamamoto Y, Hatakeyama S, Matsumura M, Koike S. Impact of the new Japanese medical specialty system on residents' career choices in general medicine: a nationwide cross-sectional study. BMC Med Educ. 2025 Jul 20;25(1):1087. doi: 10.1186/s12909-025-07707-5.
  3. Inaba T, Minami K, Ishioka H, Sekiguchi K, Watanabe A, Hatakeyama S. Isolated brain abscess caused by Aspergillus tubingensis in a patient with alcoholic liver cirrhosis. J Infect Chemother. 2025 May;31(5):102691. doi: 10.1016/j.jiac.2025.102691.
  4. Inaba T, Yamamoto Y, Hirayama K, Kobayashi T, Izumi N, Sakamoto H, Hatakeyama S, Matsumura M. Esophageal and Ileal Ulcers Caused by Hydroxycarbamide: A Case Report and Literature Review. Intern Med. 2025 Mar 15;64(6):845-849. doi: 10.2169/internalmedicine.4105-24.
  5. Hirayama K, Kanda N, Hashimoto H, Yoshimoto H, Goda K, Mitsutake N, Hatakeyama S. Antibiotic Prescription Trends in Dentistry: A Descriptive Study Using Japan's National Database. J Public Health Dent. 2025 Jun;85(2):153-159. doi: 10.1111/jphd.12663.
  6. Suzuki T, Sasahara T, Watanabe S, Kosami K, Akine D, Kinoshita Y, Cui L, Hatakeyama S. Genomic Analysis of MRSA for Evaluating Local Transmission Dynamics in Geriatric Long-Term Care Facilities in Japan. Antibiotics (Basel). 2025 Aug 30;14(9):874. doi: 10.3390/antibiotics14090874.
  7. Hashimoto H, Kanda N, Yoshimoto H, Goda K, Mitsutake N, Hatakeyama S. Significant reduction in antibiotic prescription rates in Japan following implementation of the national action plan on antimicrobial resistance (2016-20): a 9-year interrupted time-series analysis. JAC Antimicrob Resist. 2025 Apr 30;7(3):dlaf062. doi: 10.1093/jacamr/dlaf062.
  8. Yamashita S, Kanda N, Hashimoto H, Yoshimoto H, Goda K, Mitsutake N, Hatakeyama S. Trends in the healthcare burden of hepatitis C after the introduction of direct-acting antivirals in Japan, 2013-2022: A national claims database study in Japan. Int J Infect Dis. 2025 Nov;160:108043. doi: 10.1016/j.ijid.2025.108043.
  9. Muramatsu M, Akine D, Sasahara T, Suzuki T, Tamura T, Kaburagi T, Watanabe S. An older man with Bifidobacterium breve bacteremia, a rare condition in adults: A case report. Anaerobe. 2025;93:102968. doi: 10.1016/j.anaerobe.2025.102968.
  10. Kiga K, Sato'o Y, Tan XE, Miyanaga K, Nguyen HM, Li FY, Azam AH, Veeranarayanan S, Watanabe S, Aiba Y, Sasahara T, Thitiananpakorn K, Kawaguchi T, Nishikawa Y, Kinoshita-Daitoku R, Ojima S, Kondo K, Nakamura T, Tamura A, Yamashita W, Watashi K, Takahashi Y, Cui L. Development of a nonreplicative phage-based DNA delivery system and its application to antimicrobial therapies. PNAS Nexus. 2025;4(6):pgaf176. doi: 10.1093/pnasnexus/pgaf176.
  11. Hakoda S, Ishiwata A, Shimada R, Hatakeyama S, Kondo M. Fatal Septic Shock Due to Dolosigranulum pigrum Bacteremia: a Case Report. Jpn J Infect Dis. 2025 Jan 23;78(1):43-46. doi: 10.7883/yoken.JJID.2024.178.

2024

  1. 稲葉匠，山本祐，畠山修司，松村正巳．COVID-19罹患4週後に成人多系統炎症性症候群を発症した1例．日内会誌 2024；113(12)：2277-2282．
  2. Ishioka H, Fujii N, Tajima T, Suzuki S, Tsuzuki S, Matsunaga N, Ohmagari N. Cumulative antibiogram preparation among hospitals participating in the Japan Surveillance for Infection Prevention and Healthcare Epidemiology. J Infect Chemother. 2024 May;30(5):459-462. doi: 10.1016/j.jiac.2023.11.002.
  3. 田中知佳，遠藤美緒，田島太一，小泉龍士，大野茜子，坂口みきよ，藤井直樹，石岡春彦，橋本裕子，都築慎也，松永展明，早川佳代子，大曲貴夫．抗菌薬使用集計における時間や人員に関して負担把握の無記名ウェブアンケートをJ-SIPHE（感染対策連携共通プラットフォーム）利用前と後で調査した結果．日化療会誌．2024；72：364-370．
  4. Kanda N, Ohbe H, Jo T, Matsui H, Fushimi K, Hatakeyama S, Yasunaga H. Trends in inpatient antimicrobial consumption using days of therapy and days of antibiotic spectrum coverage: A nationwide claims database study in Japan. J Infect Chemother. 2024 Mar;30(3):228-235. doi: 10.1016/j.jiac.2023.10.012.
  5. Ishibashi H, Sasahara T, Katagiri O, Yamada T. Necrotizing Fasciitis with Medication-related Osteonecrosis of the Jaw. Intern Med. 2024 Mar 15;63(6):887-888. doi: 10.2169/internalmedicine.2442-23.
  6. Sugaya R, Taniguchi A, Abe M, Ozawa I, Kirito K, Hatakeyama S. A Pancreatic Collision Tumor Comprising Mantle Cell Lymphoma and Adenocarcinoma: A Case Report and Literature Review. Intern Med. 2024 Feb 15;63(4):553-558. doi: 10.2169/internalmedicine.1937-23.
  7. Seto N, Fukuchi T, Kawakami M, Nagashima M, Sadamasu K, Hatakeyama S. Seronegative HIV-1 infection in a Japanese man presenting with Pneumocystis pneumonia: Analysis of long-term antibody response and literature review. J Infect Chemother. 2024 Sep;30(9):917-921. doi: 10.1016/j.jiac.2024.02.005.
  8. Mitsutake K, Shinya N, Seki M, Ohara T, Uemura K, Fukunaga M, Sakai J, Nagao M, Sata M, Hamada Y, Kawasuji H, Yamamoto Y, Nakamatsu M, Koizumi Y, Mikamo H, Ukimura A, Aoyagi T, Sawai T, Tanaka T, Izumikawa K, Takayama Y, Nakamura K, Kanemitsu K, Tokimatsu I, Nakajima K, Akine D. Antimicrobial therapy and outcome of methicillin-resistant Staphylococcus aureus endocarditis: A retrospective multicenter study in Japan. J Infect Chemother. 2024 Sep;30(9):860-866. doi: 10.1016/j.jiac.2024.02.027.
  9. Chinen T, Kameyama M, Minami K. Successful Prompt Diagnosis of Strongyloidiasis in an Outpatient Setting at Amami Oshima Island in Japan: A Case Report. Cureus. 2024 Apr 23;16(4):e58851. doi: 10.7759/cureus.58851.
  10. Mitsutake K, Shinya N, Seki M, Ohara T, Uemura K, Fukunaga M, Sakai J, Nagao M, Sata M, Hamada Y, Kawasuji H, Yamamoto Y, Nakamatsu M, Koizumi Y, Mikamo H, Ukimura A, Aoyagi T, Sawai T, Tanaka T, Izumikawa K, Takayama Y, Nakamura K, Kanemitsu K, Tokimatsu I, Nakajima K, Akine D. Clinical characteristics and analysis of prognostic factors in methicillin-resistant Staphylococcus aureus endocarditis: A retrospective multicenter study in Japan. J Infect Chemother. 2024;30(12):1259-1265. doi: 10.1016/j.jiac.2024.06.002.
  11. Hayakawa K, Asai Y, Tajima T, Endo M, Kawabata J, Fujii N, Sakaguchi M, Ishioka H, Tsuzuki S, Matsunaga N, Ohmagari N, Fukuda H. Evaluation of antimicrobial selective pressure using the multicenter semiautomatic surveillance system Japan surveillance for infection prevention and healthcare epidemiology. J Infect Public Health. 2024 Aug;17(8):102474. doi: 10.1016/j.jiph.2024.102474.
  12. Watanabe S, Nsofor CA, Thitiananpakorn K, Tan X-E, Aiba Y, Takenouchi R, Kiga K, Sasahara T, Miyanaga K, Veeranarayanan S, Shimamori Y, Lian AYS, Nguyen TM, Nguyen HM, Alessa O, Kumwenda GP, Jayathilake S, Revilleza JEC, Baranwal P, Nishikawa Y, Li F-Y, Kawaguchi T, Sankaranarayanan S, Arbaah M, Zhang Y, Maniruzzaman, Liu Y, Sarah H, Li J, Sugano T, Ho TMD, Batbold A, Nayanjin T, Cui L. Metabolic remodeling by RNA polymerase gene mutations is associated with reduced β-lactam susceptibility in oxacillin-susceptible MRSA. mBio. 2024 Jun 12;15(6):e0033924. doi: 10.1128/mbio.00339-24.
  13. Shimamori Y, Tan XE, Li FY, Nishikawa Y, Watanabe S, Sasahara T, Miyanaga K, Aiba Y, Veeranarayanan S, Thitiananpakorn K, Nguyen HM, Batbold A, Nayanjin T, Lian AYS, Hossain S, Kawaguchi T, Alessa O, Kumwenda G, Sarangi J, Revilleza JEC, Baranwal P, Arbaah M, Maniruzzaman, Yi L, Duyen HTM, Sugano T, Sultana S, Faruk MO, Hidaka Y, Thu M, Shimojyo T, Kiga K, Cui L. Efficient synthesis of CRISPR-Cas13a-antimicrobial capsids against MRSA facilitated by silent mutation incorporation. Sci Rep. 2024 Jul 13;14(1):16225. doi: 10.1038/s41598-024-67193-5.
  14. Imai T, Kato N, Kanda N, Hashimoto H, Yamana H, Hatakeyama S. Risk of Urogenital Bacterial Infection with Sodium-Glucose Cotransporter-2 Inhibitors: A Retrospective Cohort Study Using a Claims Database. Diabetes Ther. 2024 Aug;15(8):1821-1830. doi: 10.1007/s13300-024-01613-7.
  15. Li FY, Tan XE, Shimamori Y, Kiga K, Veeranarayanan S, Watanabe S, Nishikawa Y, Aiba Y, Sato'o Y, Miyanaga K, Sasahara T, Hossain S, Thitiananpakorn K, Kawaguchi T, Nguyen HM, Yeo Syin Lian A, Sultana S, Alessa O, Kumwenda G, Sarangi J, Revilleza JEC, Baranwal P, Faruk MO, Hidaka Y, Thu M, Arbaah M, Batbold A, Maniruzzaman, Liu Y, Duyen HTM, Sugano T, Tergel N, Shimojyo T, Cui L. Phagemid-based capsid system for CRISPR-Cas13a antimicrobials targeting methicillin-resistant Staphylococcus aureus. Commun Biol. 2024 Sep 13;7(1):1129. doi: 10.1038/s42003-024-06754-w.
  16. Akine D, Sasahara T, Hirota Y, Kato H. Case Report: A Case of Sporotrichoid Cutaneous Leishmaniasis Caused by Leishmania (Viannia) peruviana. Am J Trop Med Hyg. 2024 Sep 18;111(5):953-955. doi: 10.4269/ajtmh.24-0275.
  17. Ogawa M, Ae R, Sasahara T, Omi K. Effective prevention of early resignation of newly graduated nurses: a transactional analysis. BMC Nurs. 2024 Oct 8;23(1):724. doi: 10.1186/s12912-024-02385-y.
  18. Ishioka H, Ghose A, Kingston HW, Plewes K, Leopold SJ, Srinamon K, Charunwatthana P, Ahmed M, Alam AKMS, Tuip-de Boer A, Hossain MA, Dondorp AM, Schultz MJ. The predictive capacity of biomarkers for clinical pulmonary oedema in patients with severe falciparum malaria is low: a prospective observational study. Malar J. 2024 Oct 24;23(1):320. doi: 10.1186/s12936-024-05142-3.
  19. Suzuki T, Watanabe S, Seto N, Honjo M, Cui L, Hatakeyama S. Draft genome sequence of Nocardia sp. strain JMUB6875 isolated from a patient with disseminated nocardiosis. Microbiol Resour Announc. 2024 Nov 12;13(11):e0073524. doi: 10.1128/mra.00735-24.
  20. Imai T, Hashimoto H, Kanda N, Sasabuchi Y, Matsui H, Yasunaga H, Hatakeyama S. Effect of calcium channel blockers on influenza incidence: a population-based retrospective cohort study using administrative claims data in Japan. BMJ Open. 2024 Oct 15;14(10):e084092. doi: 10.1136/bmjopen-2024-084092.

2023

  1. Suzuki J, Endo S, Suzuki T, Sasahara T, Hatakeyama S, Morisawa Y, Hayakawa M, Yamakawa K, Endo A, Ogura T, Hirayama A, Yasunaga H, Tagami T. Effect of Inhaled Ciclesonide in Non-Critically Ill Hospitalized Patients With Coronavirus Disease 2019: A Multicenter Observational Study in Japan. Open Forum Infect Dis. 2023 Nov 24;10(12):ofad571. doi: 10.1093/ofid/ofad571.
  2. Kanda N, Yamaguchi R, Yamamoto Y, Matsumura M, Hatakeyama S. Performance of serum soluble interleukin-2 receptor as a diagnostic marker for lymphoma in patients with fever. Sci Rep. 2023 Nov 1;13(1):18784. doi: 10.1038/s41598-023-44123-5.
  3. Hirayama K, Kanda N, Hashimoto H, Yoshimoto H, Goda K, Mitsutake N, Hatakeyama S. The five-year trends in antibiotic prescription by dentists and antibiotic prophylaxis for tooth extraction: a region-wide claims study in Japan. J Infect Chemother. 2023 Oct;29(10):965-970. doi: 10.1016/j.jiac.2023.06.014.
  4. Kanda N, Hashimoto H, Imai T, Yoshimoto H, Goda K, Mitsutake N, Hatakeyama S. Indirect impact of the COVID-19 pandemic on the incidence of non-COVID-19 infectious diseases: a region-wide, patient-based database study in Japan. Public Health. 2023 Jan;214:20-24. doi: 10.1016/j.puhe.2022.10.018.
  5. Endo A, Asai Y, Tajima T, Endo M, Akiyama T, Matsunaga N, Ishioka H, Tsuzuki S, Ohmagari N. Temporal trends in microbial detection during the COVID-19 pandemic: Analysis of the Japan surveillance for Infection Prevention and Healthcare Epidemiology (J-SIPHE) database. J Infect Chemother. 2023 Jan;29(1):98-101. doi: 10.1016/j.jiac.2022.08.028.
  6. Ae R, Shibata Y, Kobayashi T, Kosami K, Kuwabara M, Makino N, Matsubara Y, Sasahara T, Masuda H, Nakamura Y. Differences in Sensitivity Between the Japanese and Z Score Criteria for Detecting Coronary Artery Abnormalities Resulting from Kawasaki Disease. Pediatr Cardiol. 2023 Jan;44(1):153-160. doi: 10.1007/s00246-022-03008-6.
  7. Asano T, Wakabayashi T, Kondo Y, Okada K, Yamamuro D, Koga Y, Oka K, Sakurai M, Sawayama N, Takahashi M, Okazaki H, Ebihara K, Minami K, Morisawa Y, Hatakeyama S, Matsumura M, Ishibashi S. Serum 25-hydroxycholesterol levels are increased in patients with coronavirus disease 2019. J Clin Lipidol. 2023 Jan-Feb;17(1):78-86. doi: 10.1016/j.jacl.2022.10.012.
  8. Beppu H, Fukuda T, Otsubo N, Kawanishi T, Ogawa T, Abe Y, Endo M, Hanawa T, Sugita C, Kikkawa Y, Hatakeyama S, Yamada T, Wakai S. Serum chemokine CC-motif ligand 17 is a predictive marker of severe COVID-19 in haemodialysis patients: A retrospective observational study. Nephrology (Carlton). 2023 Apr;28(4):240-248. doi: 10.1111/nep.14151.
  9. Ishikawa Y, Sasaki R, Ishiwata A, Hatakeyama S, Matsumura M, Sato T. A case of Behçet's-like disease associated with trisomy 8-positive myelodysplastic syndrome carrying MEFV E148Q variant presented with periodic fever. Mod Rheumatol Case Rep. 2023 Jun 19;7(2):470-474. doi: 10.1093/mrcr/rxad015.
  10. Nawa H, Akine D, Tamura T, Saito K, Kaburagi T, Sasahara T. Disseminated cryptococcosis in a geriatric man following high-dose systemic steroid therapy for severe COVID-19 pneumonia. J Gen Fam Med. 2023 Sep 21;24(6):350-351. doi: 10.1002/jgf2.652.
  11. Nakamura A, Kotani K, Hatakeyama S, Obayashi S, Nagai R. Regional Variations in Coronavirus Disease 2019 Mortality in Japan: An Ecological Study. JMA J. 2023 Oct 16;6(4):397-403. doi: 10.31662/jmaj.2023-0052.

2022