業績 (Biography)
リード文を入力します。
2024
原著論文
1) Hayashi Y, Sehara Y, Watano R, Ohba K, Takayanagi Y, Sakiyaama Y, Muramatsu K, Mizukami H. Therapeutic Strrategy for Fabry Disease by Intravenous Administration of Adeno-Associated Virus 9 in a Symptomatic Mouse Model. Human Gene Therapy. 35(5-6) in press 2024
2023
原著論文
1)Ohba K, Mizukami H. Protocol for producing an adeno-associated virus vector by controlling capsid expression timing. STAR Protocols. 4. 102542. 2023
3)Hayashi Y, Sehara Y, Watano R, Ohba K, Takayanagi Y, Muramatsu K, Sakiyama Y, Mizukami H. Therapeutic strategy for Fabry disease by intravenous administration of adeno-associated virus 2 or 9 in α-galactosidase A-deficient mice. J Gen Med. In press. 2023
3)Ohba K, Sehara Y, Enoki T, Mineno J, Ozawa K, Mizukami H. Adeno-associated virus vector system controlling capsid expression improves viral quantity and quality. iScience. 26(4). 106487. 2023
2022
原著論文
1)Sehara Y, Hayashi Y, Ohba K, Uchibori R, Urabe M, Inutsuka A, Shimazaki K, Kawai K, Mizukami H. Higher Transduction Efficiency of AAV5 to Neural Stem Cells and Immature Neurons in Gerbil Dentate Gyrus Compared to AAV2 and rh10. Hum Gene Ther. 33: 76-85. 2022.
2021
原著論文
1)Ayukawa, S., Kamoshita, N., Nakayama, J., Teramoto, R., Pishesha, N., Ohba, K., Sato, N., Kozawa, K., Abe, H., Semba, K., Goda, N., Fujita, Y., Maruyama, T.: Epithelial cells remove precancerous cells by cell competition via MHC class I-LILRB3 interaction. Nat Immunol. 22: 1391-1402, 2021.
2)Baatartsogt, N., Kashiwakura, Y., Hayakawa, M., Kamoshita, N., Hiramoto, T., Mizukami, H., Ohmori, T.: A sensitive and reproducible cell-based assay via secNanoLuc to detect neutralizing antibody against adeno-associated virus vector capsid. Mol Ther Methods Clin Dev. 22: 162-171. 2021.
3)Isomi, M., Sadahiro, T., Fujita, R., Abe, Y., Yamada, Y., Akiyama, T., Mizukami, H., Shu, T., Fukuda, K., Ieda, M.: Direct reprogramming with Sendai virus vectors repaired infarct hearts at the chronic stage. Biochem Biophys Res Commun. 560: 87-92, 2021.
4)Isomi, M., Sadahiro, T., Yamakawa, H., Fujita, R., Yamada, Y., Abe, Y., Murakata, Y., Akiyama, T., Shu, T., Mizukami, H., Fukuda, K., Ieda, M.: Overexpression of Gata4, Mef2c, and Tbx5 Generates Induced Cardiomyocytes Via Direct Reprogramming and Rare Fusion in the Heart. Circulation. 143: 2123-5, 2021.
5)Koyanagi, T., Saga, Y., Takahashi, Y., Tamura, K., Yoshiba, T., Takahashi, S., Taneichi, A., Takei, Y., Urabe, M., Mizukami, H., Fujiwara, H.: Knockout of vasohibin-2 reduces tubulin carboxypeptidase activity and increases paclitaxel sensitivity in ovarian cancer. Cancer Med, 10: 2732-9, 2021.
6)Kozawa, K., Sekai, M., Ohba, K., Ito, S., Sako, H., Maruyama, T., Kakeno, M., Shirai, T., Kuromiya, K., Kamasaki, T., Kohashi, K., Tanaka, S., Ishikawa, S., Sato, N., Asano, S., Suzuki, H., Tanimura, N., Mukai, Y., Gotoh, N., Tanino, M., Natsuga, K., Soga, T., Nakamura, T., Yabuta, Y., Saitou, M., Ito, T., Matsuura, K., Tsunoda, M., Kikumori, T., Iida, T., Mizutani, Y., Miyai, Y., Kaibuchi, K., Enomoto, A., Fujita, Y.: The CD44/COL17A1 pathway promotes the formation of multilayered, transformed epithelia. Curr Biol. 31: 3086-3097, 2021.
7)Shahnaij, M., Iyori, M., Mizukami, H., Kajino, M., Yamagoshi, I., Syafira, I., Yusuf, Y., Fujiwara, K. Yamamoto, DS., Kato, H., Ohno, N., Yoshida, S.: Liver-Directed AAV8 Booster Vaccine Expressing Plasmodium falciparum Antigen Following Adenovirus Vaccine Priming Elicits Sterile Protection in a Murine Model. Front Immunol. 12: 612910, 2021.
8)Usui, N., Yoshida, M., Takayanagi, Y., Nasanbuyan, N., Inutsuka, A., Kurosu, H, Mizukami, H., Mori, Y., Kuro-O, M., Onaka T.: Roles of fibroblast growth factor 21 in the control of depression-like behaviours after social defeat stress in male rodents. J Neuroendocrinol. 33: e13026, 2021.
2020
原著論文
1) Arafune-Mishima, A., Abe, H., Tani, T., Mashiko, H., Watanabe, S., Sakai, K., Suzuki, W., Mizukami, H., Watakabe, A., Yamamori, T., Ichinohe, N.: Axonal Projections from Middle Temporal Area to the Pulvinar in the Common Marmoset. Neuroscience 446: 145-156, 2020.
2) Horiai, M., Otsuka, A., Hidema, S., Hiraoka, Y., Hayashi, R., Miyazaki, S., Furuse, T., Mizukami, H., Teruyama, R., Tamura, M., Bito, H., Maejima, Y., Shimomura, K., Nishimori, K.: Targeting oxytocin receptor (Oxtr)-expressing neurons in the lateral septum to restore social novelty in autism spectrum disorder mouse models". Sci Rep. 10: 22173, 2020.
3) Watano, R., Ohmori T, Hishikawa S., Sakata, A., Mizukami, H.: Utility of microminipigs for evaluating liver-mediated gene expression in the presence of neutralizing antibody against vector capsid. Gene Therapy 27: 427-434, 2020.
2019
原著論文
1)Ebina, T., Obara, K., Watakabe, A., Masamizu, Y., Terada, SI., Matoba, R., Takaji, M., Hatanaka, N., Nambu, A., Mizukami, H., Yamamori, T., Matsuzaki, M.: Arm movements induced by noninvasive optogenetic stimulation of the motor cortex in the common marmoset. Proc Natl Acad Sci U S A. 116:22844-22850, 2019. doi: 10.1073/pnas.1903445116. Epub 2019 Oct 21.
2)Kameda, H., Murabe, N., Odagaki, K., Mizukami, H., Ozawa, K., Sakurai, M.: Differential innervation within a transverse plane of spinal gray matter by sensorimotor cortices, with special reference to the somatosensory cortices. J Comp Neurol. 527:1401-1415, 2019. doi: 10.1002/cne.24626.
3)Kato, TM., Fujimori-Tonou, N., Mizukami, H., Ozawa, K., Fujisawa, S., Kato, T.: Presynaptic dysregulation of the paraventricular thalamic nucleus causes depression-like behavior. Sci Rep. 9:16506, 2019. doi: 10.1038/s41598-019-52984-y.
4)Kojima, K., Nakajima, T., Taga, N., Miyauchi, A., Kato, M., Matsumoto, A., Ikeda, T., Nakamura, K., Kubota, T., Mizukami, H., Ono, S., Onuki, Y., Sato, T., Osaka, H., Muramatsu, S, and Yamagata, T.: Gene therapy improves global development in aromatic l-amino acid decarboxylase. Brain, 142:322-333, 2019.
5)Miyata, S., Tominaga, K., Sakashita, E., Urabe, M., Onuki, Y., Gomi, A., Yamaguchi, T., Mieno, M., Mizukami, H., Kume, A., Ozawa, K., Watanabe, E., Kawai, K., Endo, H.: Comprehensive Metabolomic Analysis of IDH1R132H Clinical Glioma Samples Reveals Suppression of β-oxidation Due to Carnitine Deficiency. Sci Rep. 9:9787. 2019. doi: 10.1038/s41598-019-46217-5.
6)Uchibori, R., Teruya, T., Ido, H., Ohmine, K., Sehara, Y., Urabe, M., Mizukami, H., Mineno, J., Ozawa, K.: Functional Analysis of an Inducible Promoter Driven by Activation Signals from a Chimeric Antigen Receptor. Mol Ther Oncolytics 12: 16-25, 2019.
7)Yoshiba, T., Saga, Y., Uchibori, R., Urabe, M., Fujiwara, H., Matsubara, S., Mizukami, H.: CRISPR/Cas9-mediated cervical cancer treatment targeting human papillomavirus E6. Oncology Lett, 17: 2197-2206, 2019.
8)Yusuf, Y., Yoshii, T., Iyori, M., Mizukami, H., Fukumoto, S., Yamamoto, DS., Emran, TB., Amelia, F., Islam, A., Syafira, I., Yoshida, S.: A Viral-Vectored Multi-Stage Malaria Vaccine Regimen With Protective and Transmission-Blocking Efficacies. Front Immunol. 10:2412, 2019. doi: 10.3389/fimmu.2019.02412. eCollection 2019.
9)Yusuf, Y., Yoshii, T., Iyori, M., Yoshida, K., Mizukami, H., Fukumoto, S., Yamamoto, DS., Alam, A., Emran, TB., Amelia, F., Islam, A., Otsuka, H., Takashima, E., Tsuboi, T., Yoshida, S.: Adeno-Associated Virus as an Effective Malaria Booster Vaccine Following Adenovirus Priming. Front Immunol. 10:730, 2019. doi: 10.3389/fimmu.2019.00730. eCollection 2019.
2018
原著論文
1)Abe, H., Tani, T., Mashiko, H., Kitamura, N., Hayami T, Watanabe S, Sakai K, Suzuki W, Mizukami H, Watakabe A, Yamamori T, Ichinohe N.: Axonal Projections From the Middle Temporal Area in the Common Marmoset. Front Neuroanat. 12:89, 2018. doi: 10.3389/fnana.2018.00089.
2)Ebina, T., Masamizu, Y., Tanaka, Y. R., Watakabe, A., Hirakawa, R., Hirayama, Y., Hira, R., Terada, S-I., Koketsu, D., Hikosaka, K., Mizukami, H., Nambu, A., Sasaki, E., Yamamori, T., Matsuzaki, M.: Two-photon imaging of neuronal activity in motor cortex of marmosets during upper-limb movement tasks. Nat Comm. 9:1879, 2018.
3)Kondo, T., Saito, R., Otaka, M., Yoshino-Saito, K., Yamanaka, A., Yamamori, T., Watakabe, A., Mizukami, H., Schnitzer, M.J., Tanaka, K.F., Ushiba, J., Okano, H.: Calcium Transient Dynamics of Neural Ensembles in the Primary Motor Cortex of Naturally Behaving Monkeys. Cell Rep. 24:2191-5.e4, 2018.
4)Kurosaki, F., Uchibori, R., Sehara, Y., Saga, Y., Urabe, M., Mizukami, H., Hagiwara, K., Kume, A.: AAV6-mediated IL-10 expression in the lung ameliorates bleomycin-induced pulmonary fibrosis in mice. Hum Gene Ther, 29:1242-51, 2018.
5)Murabe, N., Mori, T., Fukuda, S., Isoo, N., Ohno,T.,Mizukami, H., Ozawa, K., Yoshimura, Y., Sakurai, M.: Higher primate-like direct corticomotoneuronal connections are transiently formed in a juvenile subprimate mammal. Sci Rep. 8:16536, 2018.
6)Nakamura, J., Watanabe, S., Kimura, H., Kobayashi, M., Karasawa, T., Kamata, R., Usui-Kawanishi, F., Sadatomo, A., Mizukami, H., Nagi-Miura, N., Ohno, N., Kasahara, T., Minota, S., Takahashi, M.: Adeno-associated vector-mediated interleukin-10 induction prevents vascular inflammation in a murine model of Kawasaki disease. Sci Rep. 8:7601, 2018.
7)Ohmori, T., Mizukami, H., Katakai, Y., Kawai, S., Nakamura, H., Inoue, M., Shu, T., Sugimoto, H., Sakata, Y.: Safety of intra-articular transplantation of lentivirally transduced mesenchymal stromal cells for haemophilic arthropathy in a non-human primate. Int J Hematol. 108:239-245, 2018.
8)Osada, N., Kikuchi, J., Umehara, T., Sato, S., Urabe, M., Abe, T., Hayashi, , Sugitani, M., Hanazono, Y., Furukawa, Y.: Lysine-specific demethylase 1 inhibitors prevent teratoma development from human induced pluripotent stem cells. Oncotarget 9(5):6450-6462, 2018
9)Sato, N., Saga, Y., Uchibori, R., Tsukahara, T., Urabe, M., Kume, A., Fujiwara, H., Suzuki, M., Ozawa, K., Mizukami, H.: Eradication of cervical cancer in vivo by an AAV vector that encodes shRNA targeting human papillomavirus type 16 E6/E7. Int J Oncol. 52:687-696, 2018.
10)Sehara, Y., Inaba, T., Urabe, T., Kurosaki, F., Urabe, M., Kaneko, N., Shimazaki, K., Kawai, K., Mizukami, H.: Survivin overexpression via adeno-associated virus vector Rh10 ameliorates ischemic damage after middle cerebral artery occlusion in rats. Eur J Neurosci, 48:3466-3476, 2018.
11)Sehara, Y., Shimazaki, K., Kurosaki, F., Kaneko, N., Uchibori, R., Urabe, M., Kawai, K., Mizukami, H.: Efficient transduction of adeno-associated virus vectors into gerbil hippocampus with an appropriate combination of viral capsids and promoters. Neurosci Lett.682:27-31, 2018.
12)Shimada, A., Ideno, H., Arai, Y., Komatsu, K., Wada, S., Yamashita, T., Amizuka, N., Pöschl, E., Brachvogel, B., Nakamura, Y., Nakashima, K.,Mizukami, H., Ezura, Y., Nifuji, A.: Annexin A5 involvement in bone overgrowth at the enthesis. J Bone Miner Res. 33:1532-43, 2018.
13)Skibbe, H., Reisert, M., Nakae, K., Watakabe, A., Hata, J., Mizukami, H., Okano, H,. Yamamori, T., Ishii, S.: PAT - Probabilistic Axon Tracking for Densely Labeled Neurons in Large 3D Micrographs. IEEE Trans Med Imaging. 2018 Jul 13. doi: 10.1109/TMI.2018.2855736.
14)Uchibori, R., Teruya, T., Ido, H., Ohmine, K., Sehara, Y., Urabe, M., Mizukami, H., Mineno, J., Ozawa, K.: Functional analysis of an inducible promoter driven by activation signals from a chimeric antigen receptor. Molecular Therapy - Oncolytics, 12:16-25, 2018.
2017
原著論文
1)Abe, H., Tani, T., Mashiko, M., Kitamura, N., Miyakawa, N., Mimura, K., Sakai, K., Suzuki, W., Kurotani, T., Mizukami, H., Watakabe, A., Yamamori, T., Ichinohe, N.: 3D reconstruction of brain section images for making axonal projection maps in marmosets. J Neurosci Methods 286:102-113, 2017.
2)Kurosaki, F., Uchibori, R., Mato, N., Sehara, Y., Saga, Y., Urabe, M.,Mizukami, H., Sugiyama, Y., Kume, A.: Optimization of adeno-associated virus vector-mediated gene transfer to the respiratory tract. Gene THer 24:290-297, 2017.
3)Ohmori, T., Nagao Y., Mizukami, H., Sakata, A., Muramatsu, S., Ozawa, K., Tominaga, S., Hanazono, Y., Nishimura, S., Nureki, O., Sakata, Y.: CRISPR/Cas9-mediated genome editing via postnatal administration of AAV vector cures haemophilia B mice. Sci Rep 7:4159, 2017.
4)Sehara, Y., Fujimoto, K., Ikeguchi, K., Katakai, Y., Ono, F., Takino, N., Ito, M., Ozawa, K., and Muramatsu, S.: Persistent Expression of Dopamine-Synthesizing Enzymes 15 Years after Gene Transfer in a Primate Model of Parkinson's Disease. Hum Gene Ther Clin Dev 28:74-79, 2017.