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	2017 1. Karasawa T, Takahashi M. The crystal-induced activation of NLRP3 inflammasomes in atherosclerosis. Inflammation and Regeneration 37: 18, 2017 2. Kawashima A, Karasawa T, Tago K, Kimura H, Kamata R, Usui-Kawanishi F, Watanabe S, Ohta S, Funakoshi-Tago M, Yanagisawa K, Kasahara T, Suzuki K, Takahashi M. ARIH2 ubiquitinates NLRP3 and negatively regulates NLRP3 inflammasome activation in macrophages. J Immunol 199: 3614-3622, 2017 3. Sadatomo A, Inoue Y, Ito H, Karasawa T, Kimura H, Watanabe S, Mizushina Y, Nakamuara J, Kamata R, Kasahara T, Horie H, Sata N, Takahashi M. Interaction of neutrophils with macrophages promotes interleukin-1β maturation and contributes to hepatic ischemia-reperfusion injury. J Immunol 199: 3306-3315, 2017 4. Kobayashi M, Kawanishi-Usui F, Karasawa T, Kimura H, Watanabe S, Mise N, Kayama F, Kasahara T, Hasebe N, Takahashi M. The cardiac glycoside ouabain activates NLRP3 inflammasomes and promotes cardiac inflammation and dysfunction. PLoS One 12: 176676, 2017 5. Karasawa T, Takahashi M. Role of NLRP3 inflammasomes in atherosclerosis. J Atheroscler Thromb 24: 443-451, 2017 6. Sogawa Y, Nagasu H, Iwase S, Ihoriya C, Itano S, Uchida A, Kidokoro K, Taniguchi S, Takahashi M, Satoh M, Sasaki T, Suzuki T, Yamamoto M, Horng T, Kashihara N. Infiltration of M1, but not M2, macrophages is impaired after unilateral ureter obstruction in Nrf2-deficient mice. Sci Rep 7: 8801, 2017 7. Terai S, Hashimoto Y, Orita K, Yamasaki S, Takigami J, Shinkuma T, Teraoka T, Nishida Y, Takahashi M, Nakamura H. The origin and distribution of CD68, CD163 and alpha SMA positive cells in the early phase after meniscal resection in a parabiotic rat model. Connect Tissue Res 6: 1-11, 2017 8. Yamasaki S, Hashimoto Y, Takigami J, Terai S, Takahashi M, Wakitani S, Nakamura H. Circulating Nucleated peripheral blood cells contribute to early-phase meniscal healig. J Tissue Eng Regen Med 11: 609-617, 2017 2016 1. Kimura H, Karasawa T, Usui F, Kawashima A, Endo Y, Kobayashi M, Sadatomo A, Nakamura J, Iwasaki Y, Yada T, Tsutsui H, Kasahara T, Takahashi M. Caspse-1 deficiency promotes high-fat diet-induced adipose tissue inflammation and the development of obesity. Am J Physiol Endocrinol Metab 311: E881-890, 2016 2. Kobayashi M, Usui F, Karasawa T, Kawashima A, Kimura H, Mizushina Y, Shirasuna K, Mizukami H, Kasahara T, Hasebe N, Takahashi M. NLRP3 reduces macrophage interleukin-10 production and enhances the susceptibility to doxorubicin-induced cardiotoxicity. Sci Rep 6: 26489, 2016 3. Takahashi M. Role of Interleukin-1 in the development of arteritis and abdominal aortic aneurysm. Arterioscler Thromb Vasc Biol (eLetter) 2016 4. Omori K, Kobayashi E, Komatsu H, J Rawson, Agrawal G, Parimi M, Oancea A, Valiente L, Ferreri K, Al-Abdullah IS, Kandeel F, Takahashi M, Mullen Y. Involvement of a pro-apoptotic gene BBC3 in islet injury mediated by cold preservation and re-warming. Am J Physiol Endocrinol Metab 310: E1016-E1026, 2016 5. Shirasuna K, Takano T, Seno K, Ohtsu A, Karasawa T, Takahashi M, Ohkuchi A, Suzuki H, Matsubara S, Iwata H, Kuwayama T. Palmitic acid induces interleukin-1beta secretion via NLRP3 inflammasomes and inflammatory responses through ROS production in human placental cells. J Reprod Immunol 116: 104-112, 2016 6. Okada A, Kashima Y, Tomita T, Takeuchi T, Aizawa K, Takahashi M, IkedaU. Characterization of cardiac oxidative stress levels in patients with arterial fibrillation. Heart Vessels 31: 80-87, 2016 7. Omori K, Kobayashi E, Jeffrey R, Takahashi M, Mullen Y. Mechanisms of islet damage mediated by pancreas cold ischemia/rewarming. Cyobiology 73: 126-134, 2016 2015 1. Kimura H, Usui F, Karasawa T, Kawashima A, Shirasuna K, Inoue Y, Komada T, Kobayashi M, Mizushina Y, Kasahara T, Suzuki K, Iwasaki Y, Yada T, Caturegli P, Takahashi M. Immunoproteasome LMP7 deficiency improves obesity and metabolic disorders. Sci Rep 5: 15883, 2015 2. Shirasuna K, Karasawa T, Usui F, Kobayashi M, Komada T, Kimura H, Kawashima A, Ohkuchi A, Taniguchi S, Takahashi M. NLRP3 deficiency improves angiotensin II-induced hypertension but not fetal growth restriction during pregnancy. Endocrinology 156: 4281-4292, 2015 3. Komada T, Usui F, Kawashima A, Kimura H, Karasawa T, Inoue Y, Kobayashi M, Mizushina Y, Kasahara T, Taniguchi S, Muto S, Nagata D, Takahashi M. Role of NLRP3 inflammasomes for rhabdomyolysis-induced acute kidney injury. Sci Rep 5: 10901, 2015 4. Karasawa T, Kawashima A, Usui F, Kimura H, Shirasuna K, Inoue Y, Komada T, Kobayashi M, Mizushina Y, Sagara J, Takahashi M. Oligomerized CARD16 promotes caspase-1 assembly and IL-1β processing. FEBS Open Bio 5: 348-356, 2015 5. Mizushina Y, Shirasuna K, Usui F, Karasawa T, Kawashima A, Kimura H, Kobayashi M, Komada T, Inoue Y, Mato N, Yamasawa H, Latz E, Iwakura Y, Kasahara T, Bando M, Sugiyama Y, Takahashi M. NLRP3 protein deficiency exacerbates hyperoxia-induced lethality through Stat3 protein signaling independent of interleukin-1beta. J Biol Chem 290: 5065-5077, 2015 6. Usui F, Shirasuna K, Kimura H, Tatsumi K, Kawashima A, Karasawa T, Yoshimura K, Aoki H, Tsustui H, Noda T, Sagara J, Taniguchi S, Takahashi M. Inflammasome activation by mitochondrial oxidative stress in macrophages leads to the development of angiotensin II-induced aortic aneurysm. Arterioscler Thromb Vasc Biol 35: 127-136, 2015 7. Shirasuna K, Usui F, Karasawa T, Kimura H, Kawashima A, Mizukami H, Ohkuchi A, Nishimura S, Sagara J, Noda T, Ozawa K, Taniguchi S, Takahashi M. Nanosilica-induced placental inflammation and pregnancy complications: Different roles of the inflammasome components NLRP3 and ASC. Nanotoxicology 9: 554-567, 2015 8. Usui F, Kobayashi M, Takahashi M. Letter regarding article “Inhibition of interleukin-1beta decrease aneurysm formation and progression in murine model of thoracic aortic aneurysm”. Circulation 131: e399, 2015 9. Inoue Y, Takahashi M. Comment on “Radiation exposure induces inflammatory pathway activation in immune cells”. J Immunol 194: 5039, 2015 10. Karasawa T, Takahashi M. Letter regarding article “Anti-inflammatory and anti-atherogenic effects of the inflammasome NLRP3 inhibitor, arglabin, in ApoE2.Ki mice fed a high fat diet” Circulation 132: e249, 2015 11. Inoue Y, Sadatomo A, Takahashi M. Role of NLRP3 inflammasomes in hepatic ischemia-reperfusion injury. Inflammation and Regeneration 35: 61-68, 2015 12. Kimura H, Caturegli P, Takahashi M, Suzuki K. New insights into the function of the immunoproteasome in immune and non-immune cells. J Immunol Res 2015: 541984, 2015 13. Karasawa T, Takahashi M. RIP140 as a novel therapeutic target in the treatment of atherosclerosis. J Mol Cell Cardiol 81: 136-138, 2015 14. Takahashi M. High-mobility group box 1 protein in myocardial infarction: Should it be stimulated or inhibited. J Atheroscler Thromb 22: 553-554, 2015 15. Gautam M, Fujita D, Kimura K, Ichikawa H, Izawa A, Hirose M, Kashihara T, Yamada M, Takahashi M, Ikeda U, Shiba Y. Transplantation of adipose-tissue-derived stem cells improves cardiac contractile function and electrical stability in a rat myocardial infarction model. J Mol Cell Cardiol 81: 139-149, 2015 16. Kadoya H, Sato M, Sasaki T, Taniguchi S, Takahashi M, Kashihara N. Excess aldosterone is a critical danger signal for inflammasome activation in the development of renal fibrosis in mice. FASEB J 29: 3899-3910, 2015 17. Nagayama S, Ohkuchi A, Shirasuna K, Takahashi K, Suzuki H, Hirashima C, Sakata A, Nishimura S, Takahashi M, Matsubara S. The frequency of peripheral blood CD4+Fox3+ regulatory T cells in women with preeclampsia and those with high risk factors for preeclampsia. Hypertens Preg 34: 443-455, 2015 18. Yano K, Yasuda H, Takaoka K, Takahashi M, Nakamura H, Imai Y, Wakitani S. Fate, origin and roles of cells within free bone grafts. J Orthop Sci 20: 390-396, 2015 19. Takahashi M. Role of innate immune system in inflammation and cardiac remodeling after myocardial infarction. Curr Vascular Pharm 13: 20-25, 2015 2014 1. Inoue Y, Shirasuna K, Kimura H, Usui F, Kawashima A, Karasawa T, Tago K, Dezaki K, Nishimura S, Sagara J, Noda T, Iwakura Y, Tsutsui H, Taniguchi S, Yanagisawa K, Yada T, Yasuda Y, Takahashi M. NLRP3 regulates neutrophil function and contributes to hepatic ischemia-reperfusion injury independently of inflammasomes. J Immunol 192: 4342-4351, 2014 2. Komada T, Usui F, Shirasuna K, Kawashima A, Kimura H, Karasawa T, Nishimura S, Sagara J, Noda T, Taniguchi S, Muto S, Nagata D, Kusano E, Takahashi M. ASC in renal collecting duct epithelial cells contributes to inflammation and injury after unilateral ureteral obstruction. Am J Pathol 184: 1287-1298, 2014 3. Hara K, Shirasuna K, Usui F, Karasawa T, Kimura H, Kawashima A, Ohkuchi A, Matsuyama S, Kimura K, Takahashi M. IFNT attenuates uptake of nanoparticle and secretion of interleukin-1beta in macrophages. PLoS One 9: e113974, 2014 4. Takahashi M. NLRP3 inflammasome as a novel player in myocardial infarction. Int Heart J 55: 101-105, 2014 5. Takahashi M. Letter regarding article “Targeting interleukin-1 in heart disease”. Circulation 130: e62, 2014 6. Takahashi M. Reply to letter regarding article “NLRP3 inflammasome as a therapeutic target in myocardial infarction”. Int Heart J 55: 380, 2014 7. Ishizuka Y, Nakayama K, Ogawa A, Makishima S, Boonvist S, Hirao A, Iwasaki Y, Yada T, Yanagisawa Y, Miyashita H, Takahashi M, Iwamoto S. TRIB1 down-regulates hepatic lipogenesis and glycogenesis via multiple molecular interactions. J Mol Endocrinol 52: 145-158, 2014 8. Ninomiya T, Hiraga T, Hosoya A, Ohnuma K, Ito Y, Takahashi M, Ito S, Asashima M, Nakamura H. Enhanced bone-forming activity of side population cells in the periodontal ligament. Cell Transplant 23: 691-701, 2014 9. Okano T, Wakitani S, Okabe T, Takahashi M, Koike T, Nakamura H. Nucleated cells circulating in the peripheral blood contribute to the repair of osteochondral defects in the early phase of healing. J Tissue Eng Regen Med 8: 414-420, 2014 10. Motoki H, Koyama J, Aizawa K, Koshikawa M, Kasai H, Izawa A, Tomita T, Kumazaki S, Takahashi M, Ikeda U. Impact of azelnidipine and amlodipine on left ventricular mass and longitudinal function in hypertensive patients with left ventricular hypertrophy. Echocardiography 31:1230-1238, 2014 11. Yamasaki, Hashimoto Y, Takigami J, Terai S, Takahashi M, Nakamura H. Circulating blood cells contribute to early-phase meniscal healing. J Tissue Eng Regen Med 8: 414-420, 2014