自治医大HPに戻る
	2021 1. Anzai F, Karasawa T, Komada T, Yamada N, Miura Y, Sampilvanjil A, Baatarjav C, Fujimura K, Matsumura T, Tago K, Kurosu H, Takeishi Y, Kuro-o M. Takahashi M. Calciprotein particles induce IL-1β/α-mediated inflammation through NLRP3 inflammasome-dependent and -independent mechanisms. ImmunoHorizons 5: 602-614, 2021 2. Takahashi M. NLRP3 inflammasome as a common denominator of atherosclerosis and abdominal aortic aneurysm. Circ J 85: 2129-2136, 2021 3. Shiraishi Y, Kimura A, Kimura H, Ohmori T, Takahashi M, Takeshita K. Deletion of inflammasome adaptor protein ASC enhances functional recovery after spinal cord injury in mice. J Orthop Sci 26: 487-493, 2021 4. Wada Y, Umeno R, Nagasu H, Kondo M, Tokuyama A, Kadoya H, Kidokoro K, Taniguchi S, Takahashi M, Sasaki T, Kashihara N. Endothelial dysfunction accelerates impairment of mitochondrial function in ageing kidney via inflammasome activation. Int J Mol Sci 22: 9269, 2021 5. Hirata Y, Shimazaki S, Suzuki S, Henmi Y, Komiyama H, Kuwayama T, Iwata H, Karasawa T, Takahashi M, Takahashi H, Shirasuna K. β-hydroxybutyrate suppresses NLRP3 inflammasome-mediated placental inflammation and lipopolysaccharide-induced feral abortion. J Reprod Immunol 148: 103433, 2021 2020 1. Ito H, Kimura H, Karasawa T, Hisata S, Sadatomo A, Inoue Y, Yamada N, Aizawa E, Hishida E, Kamata R, Komada T, Watanabe S, Kasahara T, Suzuki T, Horie H, Kitayama J, Sata N, Takahashi M. NNLRP3 inflammasome activation in lung vascular endothelial cells contributes to intestinal ischemia/reperfusion-induced acute lung injury. J Immunol 205: 1393-1405, 2020 2. Aizawa E, Karasawa T, Watanabe S, Komada T, Kimura H, Kamata R, Ito H, Hishida E, Yamada N, Kasahara T, Mori Y, Takahashi M. GSDME-dependent incomplete pyroptosis permits selective IL-1α release under caspase-1 inhibition. iScience 23: 101070, 2020 3. Watanabe S, Usui-Kawanishi F, Komada T, Karasawa T, Kamata R, Yamada N, Kimura H, Dezaki K, Ohmori T, Takahashi M. ASC regulates platelet activation and contributes to thrombus formation independent of NLRP3 inflammasome. Biochem Biophys Res Commun 531: 125-132, 2020 4. Watanabe S, Usui-Kawanishi F, Komada T, Karasawa T, Kimura H, Kamata R, Inoue Y, Mise N, Kasahara T, Takahashi M. Glucose regulates hypoxia-induced NLRP3 inflammasome activation in macrophages. J Cell Physiol 235: 7554-7566, 2020 5. Shirasuna K, Karasawa T, Takahashi M. Role of the NLRP3 inflammasome in preeclampsia. Front Endocrinol 11: 80, 2020 6. Yamada N, Karasawa T, Kimura H, Watanabe S, Komada T, Kamata R, Sampilvanjil A, Ito J, Nakagawa K, Kuwata H, Hara S, Sakuma Y, Sata N, Takahashi M. Ferroptosis driven by radical oxidation of n-6 fatty acids mediates acetaminophen-induced acute liver failure. Cell Death Dis 11: 144, 2020 7. Sampilvanjil A, Karasawa T, Yamada N, Higashi T, Baatarjav C, Komada T, Watanabe S, Kamata R, Ohno N, Takahashi M. Cigarette smoke extract induces ferroptosis in vascular smooth muscle cells. Am J Physiol Heart Circ Physiol 318: H508-518, 2020 （Best Research Article Award@ AJP-Heart and Circulatory Physiology 2022） 8. Yamada N, Karasawa T, Wakiya T, Sadatomo A, Ito H, Kamata R, Watanabe S, Komada T, Kimura H, Sanada Y, Sakuma Y, Mizuta K, Sata N, Takahashi M. Iron overload as a risk factor for hepatic ischemia-reperfusion injury in liver transplantation: potential role of ferroptosis. Am J Transplant 20: 1606-1618, 2020 9. Yamada N, Karasawa T, Takahashi M. Role of ferroptosis in acetaminophen-induced hepatotoxicity. Arch Toxicol 94: 1769-1770, 2020 10. Yamada N, Komada T, Ohno N, Takahashi M. Acetaminophen-induced hepatotoxicity: Different mechanisms of acetaminophen-induced ferroptosis and mitochondrial damage. Arch Toxicol 94: 2255-2257, 2020 11. Anzai F, Watanabe S, Kimura H, Kamata R, Karasawa T, Komada T, Nakamura J, Nagi-Miura N, Ohno N, Takeishi Y, Takahashi M. Crucial role of NLRP3 inflammasome in a murine model of Kawasaki disease. J Mol Cell Cardiol 138: 185-196, 2020 12. Sano M, Shimazaki S, Kaneko Y, Karasawa T, Takahashi M, Ohkuchi A, Takahashi H, Kurosawa A, Torii Y, Iwata H, Kuwayama T, Shirasuna K. Palmitic acid activates NLRP3 inflammasome and induces placental inflammation during pregnancy in mice. J Reprod Develop 66: 241-248, 2020 13. Nagayama S, Shirasuna K, Nagayama M, Nishimura S, Takahashi M, Matsubara S, Ohkuchi A. Decreased circulating levels of plasmacytoid dendritic cells in women with early-onset preeclampsia. J Reprod Immunol 141: 103170, 2020 2019 1. Mizushina Y, Karasawa T, Aizawa K, Kimura H, Watanabe S, Kamata R, Komada T, Mato N, Kasahara T, Koyama S, Bando M, Hagiwara K, Takahashi M. Inflammasome-independent and atypical processing of IL-1β contributes to acid aspiration-induced acute lung injury. J Immunol 203: 236-246, 2019 2. Hishida E, Ito H, Komada T, Karasawa T, Kimura H, Watanabe S, Kamata R, Aizawa E, Kasahara T, Morishita Y, AkimotoT, Nagata D, Takahashi M. Crucial role of NLRP3 inflammasome in the development of peritoneal dialysis-related peritoneal fibrosis. Sci Rep 9: 10363, 2019 3. Ito H, Sadatomo A, Inoue Y, Yamada N, Aizawa E, Hishida E, Kamata R, Karasawa T, Kimura H, Watanabe S, Komada T, Horie H, Kitagawa J, Sata N, Takahashi M. Role of TLR5 in inflammation and tissue damage after intestinal ischemia-reperfusion injury. Biochem Biophys Res Commun 519: 15-22, 2019 4. Takahashi M. Cell-specific roles of NLRP3 inflammasome in myocardial infarction. J Cardiovasc Pharmacol 74: 188-193, 2019 5. Takahashi M. Role of NLRP3 inflammasome in cardiac inflammation and remodeling after myocardial infarction. Biol Pharm Bull 42: 518-523, 2019 6. Shirasuna K, Karasawa T, Takahashi M. Exogenous nanoparticles and endogenous crystalline molecules as danger signals for the NLRP3 inflammasomes. J Cell Physiol 234: 5436-5450, 2019 7. Yamada N, Katano T, Hirata Y, Okada N, Sanada Y, Ihara Y, Urahashi T, Ushijima K, Karasawa T, Takahashi M, Mizuta K. Serum Mac2 binding protein glycosylation isomer predicts the activation of hepatic stellate cells after liver transplantation. J Gastroenterol Hepatol 34: 418-424, 2019 8. Karasawa T, Takahashi M. Saturated fatty acid-crystals activate NLRP3 inflammasome. Aging 11: 1613-1614, 2019 9. Komada T, Muruve DA. The role of inflammasomes in kidney disease. Nat Rev Nephrol 15: 501-520, 2019 10. Zuurbier CJ, Abbate A, Cabrera-Fuentes HA, Cohen MV, Collino M, De Kleijn DPV, Downey JM, Pagliaro P, Preissner KT, Takahashi M, Davidson SM, on behalf of the EU-CARDIOPROTECTION COST Action (CA16225). Innate immunity as a target for acute cardioprotection. Cardiovasc Res 115: 1131-1142, 2019 11. Mishra PK, Adameova A, Hill J, Baines CP, Kang P, Downey JM, Narula J, Takahashi M, Abbate A, Piristine H, Su S, Higa J, Kawasaki N, Matsui T. Guidelines for evaluating myocardial cell death. Am J Physiol Heart Circ Physiol 317: H891-922, 2019 12. Murakami T, Ruengsinpinya L, Nakamura E, Takahata Y, Hata K, Okae H, Taniguchi S, Takahashi M, Nishimura R. G protein subunit beta 1 negatively regulates NLRP3 inflammasome activation. J Immunol 202: 1942-1947, 2019 13. Matsushita N, Ishida N, Ibi M, Saito M, Takahashi M, Taniguchi S, Iwakura Y, Morino Y, Taira E, Sawa Y, Hirose M. IL-1β plays an important role in pressure overload-induced atrial fibrillation in mice. Biol Pharm Bull 42: 543-546, 2019 14. Usui-Kawanishi F, Takahashi M, Sakai H, Suto W, Kai Y, Hiraishi K, Kurahara LH, Hori M, Inoue R. Implications of immune-inflammatory responses in smooth muscle dysfunction and disease. J Smooth Muscle Res 55: 81-107, 2019 2018 1. Karasawa T, Kawashima A, Usui-Kawanishi F, Watanabe S, Kimura H, Kamata R, Shirasuna K, Koyama Y, Sato-Tomita A, Matsuzaka T, Tomoda H, Park SY, Shibayama N, Shimano H, Kasahara T, Takahashi M. Saturated fatty acids undergo intracellular crystallization and activate the NLRP3 inflammasome in macrophages. Arterioscler Thromb Vasc Biol 38: 744-756, 2018 2. Nakamura J, Watanabe S, Kimura H, Kobayashi M, Karasawa T, Kamata R, Usui-Kawanishi F, Sadatomo A, Mizukami H, Nagi-Miura N, Ohno N, Kasahara T, Minota S, Takahashi M. Adeno-associated vector-mediated interleukin-10 induction prevents vascular inflammation in a murine model of Kawasaki disease. Sci Rep 8: 7601, 2018 3. Wakabayashi T, Takahashi M, Yamamoto D, Karasawa T, Takei A, Takei S, Yamazaki H, Nagashima S, Ebihara K, Takahashi M, Ishibashi S. Inflammasome activation aggravates cutaneous xanthomatosis and atherosclerosis in acyl-CoA cholesterol acyltransferase 1 deficiency in bone marrow. Arterioscler Thromb Vasc Biol 38: 2576-2589, 2018 4. Sakai K, Nagashima S, Wakabayashi T, Bayasgalan T, Hayakawa H, Hayakawa M, Karasawa T, Ohashi K, Yamazaki H, Takei A, Takei S, Yamamoto D, Takahashi M, Yagyu H, Osuga J, Takahashi M, Tominaga S, Ishibashi S. Myeloid HMG-CoA reductase determines atherosclerosis by modulating migration of macrophages. Arterioscler Thromb Vasc Biol 38: 2590-2600, 2018 5. Sogawa Y, Hagasu H, Uchida A, KidokoroK, Taniguchi S, Takahashi M, Kadoya H, Satoh M, Sasaki T, Kashihara N. The eNOS-NO pathway attenuates kidney dysfunction via suppression of inflammasome activation in aldosterone-induced renal injury model mice. PLoS One 13: e0203823, 2018 2. Nakamura J, Watanabe S, Kimura H, Kobayashi M, Karasawa T, Kamata R, Usui-Kawanishi F, Sadatomo A, Mizukami H, Nagi-Miura N, Ohno N, Kasahara T, Minota S, Takahashi M. Adeno-associated vector-mediated interleukin-10 induction prevents vascular inflammation in a murine model of Kawasaki disease. Sci Rep 8: 7601, 2018 3. Wakabayashi T, Takahashi M, Yamamoto D, Karasawa T, Takei A, Takei S, Yamazaki H, Nagashima S, Ebihara K, Takahashi M, Ishibashi S. Inflammasome activation aggravates cutaneous xanthomatosis and atherosclerosis in acyl-CoA cholesterol acyltransferase 1 deficiency in bone marrow. Arterioscler Thromb Vasc Biol 38: 2576-2589, 2018 4. Sakai K, Nagashima S, Wakabayashi T, Bayasgalan T, Hayakawa H, Hayakawa M, Karasawa T, Ohashi K, Yamazaki H, Takei A, Takei S, Yamamoto D, Takahashi M, Yagyu H, Osuga J, Takahashi M, Tominaga S, Ishibashi S. Myeloid HMG-CoA reductase determines atherosclerosis by modulating migration of macrophages. Arterioscler Thromb Vasc Biol 38: 2590-2600, 2018 5. Sogawa Y, Hagasu H, Uchida A, KidokoroK, Taniguchi S, Takahashi M, Kadoya H, Satoh M, Sasaki T, Kashihara N. The eNOS-NO pathway attenuates kidney dysfunction via suppression of inflammasome activation in aldosterone-induced renal injury model mice. PLoS One 13: e0203823, 2018